摘要(Abstract)：

<正> Aim To evaluate the hemodynamic and electrophysiologic effects ofintravenous and oral sotalol and its tolerance of long-term oral therapy in pts.with Life-Threatening Vantricular tachyarrhythmias.Methods twenty-throe pts.,17 with sustained ventricular tachycardias,6 with ventricularfibrilation were studied.16 pts.were postmyocardial infarction,4 were rightvuntricolar dispiasia and 3 were dilated cardiomyopathy.Results Sotalotprevented the induction of arrhythmias in 34.3% with bolus intravenousinjection(1mg/kg body weight)and 60.8% with oral(160mg twice daily for10 to 14 days).Intravenous and oral sotalol each induce a comparablereduction in heart rate(78±6 vs 68±6,60±6min~(-1) p<0.01),decrease incardiac index(3.2±0.4 vs 2.8±0.3,2.4±0.3L/min.m~(-2);p<0.01),increase inleft vantrinular filling pressure(1.2±0.4 vs 1.5±0.4,1.9±0.7kPa;p<0.01),as well as in systemic vascular resistanca(1255±153 vs 1446±176,p<0.05;1537±160,p<0.01),The stroke volume increased significantly after sotalolintravanoas(72±11 vs 80±10ml,p<0.05),but not changed at peak actionafter oral sotalol(79±11,p>0.05).Neither intravenous nor oral sotalol had asignificant effect on systemic and pulmonary arterial pressures,as well asstroke work indexes.During a follow-up of 3 to 6 months,oral sotalolprevented the recurrent of arrhythmias in 12 of 16 pts.who were responsedto electrophysiology testing.Congestive heart failure associated with amarked bradycardia developed in one patient.This patient was managedwith a reduction in the dosage and with a regimen of digoxin andfurosemide.Conclusion Sotalol provided effective prophylaxis againstlife-threatening Ventricular tachyarrhythmias.It exerted significant negativehemodynamics effects but with quite good clinical tolerance,even in pts.with compromised heart function.

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