摘要(Abstract)：

<正> The purpose of this study is to evaluate the relation between the plasma ofnitric oxide(NO),endothelin(ET),interleukin-2(IL-2),tunmor necrosisfactor(TNF)and the severity of the coronary atherosclerosis,as well asto measure above-mentioned plasma bioactive substances before and aftertreadmill exercise testing in patients with coronary heart disease(CHD)and normal subjects.Materials and Methods,30 patients diagnosed bycoronary angiograph(CAG)had single-vessel stenosis at least and morethan 50% reduction in luminal diameter.The blood sample was withdrawnbefore exercise and at the moment when the patients complained of chestpain and upon observation of≥1mm ST-segment depression with ahorizontal during treadmill exercise testing.Normsl control groupconsisted of 10 subjects,The blood sample was withdrawn before exerciseand at the end of exercise.Plasma ET,IL-2 sad TNF were measured byradioimmunoassary,and plasma NO was measured by indirect calorimeter.Results,After exercise the plasma NO levels reduced from 4.45±2.28 to3.55±2.28μg/ml(P<0.01),ET increased from 8.48±4.97 to 12.3±7.65 pg/ml(P<0.05),IL-2 increased from 10.76±3.70 to 16.19±5.62ng/ml (P<0.0001),TNF increased from 13.33±6.32 to 17.45±6.40(P<0.05)in patients with exerclse-induced angina of coronary heartdisease.There were significant positive correlation between the score ofcoronary artery atenosis and plasma levels of ET and IL-2 before exercise,In comparison with plasma levels of normal control group,ET and TNFwere significantly high but NO and IL-Z had no much change.DiscussionThe study showed that coronary atherosclerosis patients presentendothelial dysfunction.At the same time,it also suggests that aninflammatory response and immunization may mediate the formation ofatherosclerosis.There were significant high level of NO and no significantchanges of ET、IL-g and TNF levels of plasma after exercise in normalcontrol group,and the plasma levels at IL-2,ET as well as TNF weresignificantly high after exercise in patients with atherosclerosis,but theplasma level of NO had no much change.All above-mentioned resultsindicate further that endothelium-dependent relaxation response may beimpaired and endothelial cells may be defective to secrete NO.

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