郑斌,吴铮,李文铮

• 1:首都医科大学附属北京安贞医院心内科北京市心肺血管疾病研究所

摘要(Abstract)：

目的探讨合并肾动脉狭窄(RAS)的高血压病患者血炎性因子水平的变化及意义。方法纳入2016年6月至2017年12月来首都医科大学附属北京安贞医院就诊的207例高血压病患者,其中包括RAS患者32例及非RAS患者175例,按照患者年龄、性别、糖尿病、冠心病作1∶4配对,共有160例患者入选,分为RAS组(32例)和非RAS组(128例),分析两组患者血超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)以及白细胞介素-6(IL-6)水平。结果两组患者hs-CRP、TNF-α以及IL-6水平均呈非正态分布,hs-CRP及TNF-α水平比较,差异均无统计学意义(均P>0.05);RAS组患者IL-6水平显著高于非RAS组患者[4.75(3.42,8.41)pg/ml比3.70(2.32,5.50)pg/ml,P=0.033],差异有统计学意义。两组患者hs-CRP、TNF-α以及IL-6水平经对数转换后均呈正态分布,lg hs-CRP值和lg TNF-α值比较,差异均无统计学意义(均P>0.05);RAS组患者lg IL-6值显著高于非RAS组患者[(0.71±0.30)比(0.59±0.28),P=0.026],差异有统计学意义。RAS组冠心病患者IL-6水平显著高于非RAS组冠心病患者[5.50(3.80,9.72)pg/ml比3.90(2.58,7.02)pg/ml,P=0.033],RAS组冠心病患者lg IL-6值显著高于非RAS组冠心病患者[(0.79±0.30)比(0.63±0.29),P=0.032],差异均有统计学意义。lg IL-6值与冠状动脉造影SYNTAX评分呈正相关(r=0.334,P=0.033)。结论 RAS组高血压患者血IL-6水平的增加,或可部分解释与RAS相关远期不良事件的发生。

关键词(KeyWords)： 肾动脉狭窄;高血压病;白细胞介素-6;超敏C反应蛋白;肿瘤坏死因子-α

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 郑斌,吴铮,李文铮

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