卜海伟,刘静怡,王明慧,张英,王文丰,李舒承,张娜,黄贤胜,孙王乐贤

• 1:河北省承德医学院附属医院心脏内科承德市心血管病研究所

摘要(Abstract)：

目的探讨不同性别急性冠状动脉综合征(ACS)患者的临床特征及影响预后的因素。方法连续入选2014年1月至2015年10月承德医学院附属医院心脏内科行经皮冠状动脉介入治疗并符合纳入标准的ACS患者845例,其中女207例(女性组),男638例(男性组),收集患者的基线资料及所有临床资料,建立冠状动脉造影数据库,规律随访,进行预后分析。结果两组患者主要不良心血管事件及全因死亡率比较,差异均无统计学意义(均P>0.05)。女性组患者年龄[(60.3±9.8)岁比(55.8±10.3)岁,P<0.001]、发病到首次就诊时间[365(14,460)d比60(5,1095)d,P<0.001]、疾病加重到就诊时间[168(24,360)h比96(9,360)h,P=0.007]、高血压病(70.0%比52.5%,P<0.001)、血脂异常(63.3%比53.4%,P=0.013)、2型糖尿病(32.4%比21.2%,P<0.001)比例等显著高于男性组,差异均有统计学意义。多因素Cox风险回归模型显示,因心脏事件再入院、入院48 h内室性心动过速(室速)或心室颤动(室颤)、入院时白细胞升高、B型脑利钠肽>100 pg/ml、左心室肥厚均为影响ACS患者预后的独立危险因素,其HR值分别为4.590、4.174、2.861、2.199、3.503(均P<0.05)。结论女性ACS患者较男性初始患病年龄大,就诊延迟更为明显,合并高血压病、血脂异常、2型糖尿病等代谢性危险因素患病率高,但女性与男性患者远期预后差异无统计学意义。

关键词(KeyWords)： 急性冠状动脉综合征;经皮冠状动脉介入治疗;危险因素;预后

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 卜海伟,刘静怡,王明慧,张英,王文丰,李舒承,张娜,黄贤胜,孙王乐贤

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