心脏收缩力调节器用于心力衰竭的机制和临床研究Mechanism and clinical study of cardiac contractility modulation for heart failure
卢群,梁潇,白玲,朱丹军,薛小临,韩克
摘要(Abstract):
心脏收缩力调节器(CCM)作为救治慢性射血分数降低的心力衰竭(HFrEF)的新型植入性电子治疗装置,因可增强心室肌收缩力、改善患者症状体征和心功能指标甚至远期预后,已迅速成为心血管领域倍受关注的热点。本文综述了CCM治疗HFrEF的机制和临床研究,并根据其机制和信号传递算法对其在射血分数保留的心力衰竭(HFpEF)、心脏再同步化治疗(CRT)反应不佳、合并心房颤动的HFrEF患者中的疗效进一步分析和展望,以期推动CCM可以满足更多、不同临床情况的心力衰竭患者的需求。
关键词(KeyWords): 心脏收缩力调节器;射血分数降低的心力衰竭;机制研究;临床研究
基金项目(Foundation): 陕西省科技惠民计划项目(2016HM-04);; 陕西省重点研发项目(2020GXLH-Y-015);; 国家自然科学基金项目(8210021403)
作者(Author): 卢群,梁潇,白玲,朱丹军,薛小临,韩克
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