郭雨龙,郭丽君

• 1:北京大学第三医院心血管内科

摘要(Abstract)：

<正>微循环是冠状动脉循环的重要组成部分。越来越多的研究显示,微循环结构和功能受损是冠心病患者不良预后的独立预测因素[1-3]。最早用于评估微循环状态的参数是冠状动脉血流储备(coronary flow reserve,CFR),但CFR受血压、心率、心外膜狭窄病变及血流动力学等因素影响,重复性差,限制了其临床应用[4-5]。微循环阻力指数(index of microcirculatory resistance,IMR)是近年来用于临床的新评价

关键词(KeyWords)：

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 郭雨龙,郭丽君

参考文献(References)：

• [1]Lerman A,Holmes DR,Herrmann J,et al.Microcirculatory dysfunction in ST-elevation myocardial infarction:cause,consequence,or both?Eur Heart J,2007,28:788-797.
• [2]Ito H,Maruyama A,Iwakura K,et al.Clinical implications of the'no reflow'phenomenon.A predictor of complications and left ventricular remodeling in reperfused anterior wall myocardial infarction.Circulation,1996,93:223-228.
• [3]Rezkalla SH,Kloner RA.No-reflow phenomenon.Circulation,2002,105:656-662.
• [4]Eshtehardi P,Luke J,McDaniel MC,et al.Intravascular imaging tools in the cardiac catheterization laboratory:comprehensive assessment of anatomy and physiology.J Cardiovasc Transl Res,2011,4:393-403.
• [5]Ng MK,Yeung AC,Fearon WF.Invasive assessment of the coronary microcirculation:superior reproducibility and less hemodynamic dependence of index of microcirculatory resistance compared with coronary flow reserve.Circulation,2006,113:2054-2061.
• [6]高秀来,于恩华.人体解剖学.北京:北京大学医学出版社,2004:161-163.
• [7]邵耕,胡大一.现代冠心病.北京:北京大学医学出版社,2006:26-35.
• [8]Puymirat,Muller O,Sharif F,et al.Fractional flow reserve:concepts,applications and use in France in 2010.Arch Cardiovasc Dis,2010,103:615-622.
• [9]Liu Y,Gutterman DD.Vascular control in humans:focus on the coronary microcirculation.Basic Res Cardiol,2009,104:211-227.
• [10]朱大年,吴博威,樊小力.生理学.7版.北京:人民卫生出版社,2011:99-126.
• [11]Lim MJ,Kern MJ.Coronary pathophysiology in the cardiac catheterization laboratory.Curr Probl Cardiol,2006,31,493-550.
• [12]Kern MJ,Lerman A,Bech JW,et al.Physiological assessment of coronary artery disease in the cardiac catheterization laboratory:a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization,Council on Clinical Cardiology.Circulation,2006,114:1321-1341.
• [13]张永珍,郭丽君.冠脉内血流动力学检测基础及临床应用研究进展.临床内科杂志,2010,27:443-446.
• [14]Yong AS,Ho M,Shah MG,et al.Coronary microcirculatory resistance is independent of epicardial stenosis.Circ Cardiovasc Interv,2012,5:103-108.
• [15]Matsuo H,Watanabe S,Watanabe T,et al.Prevention of noreflow/slow-flow phenomenon during rotational atherectomy--a prospective randomized study comparing intracoronary continuous infusion of verapamil and nicorandil.Am Heart J,2007,154:994.e1-994.e6.
• [16]Ito N,Nanto S,Doi Y,et al.High index of microcirculatory resistance level after successful primary percutaneous coronary intervention can be improved by intracoronary administration of nicorandil.Circ J,2010,74:909-915.
• [17]Ito N,Nanto S,Doi Y,et al.Beneficial effects of intracoronary nicorandil on microvascular dysfunction after primary percutaneous coronary intervention:demonstration of its superiority to nitroglycerin in a cross-over study.Cardiovasc Drugs Ther,2013,27:279-287.
• [18]Bonello L,Ait Mokhtar O,Lemesle G,et al.Incidence and predictors of microvascular dysfunction assessed by the index of microcirculatory resistance following primary PCI for ST-elevation myocardial infarction.Int J Cardiol,2011,146:465-467.
• [19]McGeoch R,Watkins S,Berry C,et al.The index of microcirculatory resistance measured acutely predicts the extent and severity of myocardial infarction in patients with ST-segment elevation myocardial infarction.JACC Cardiovasc Interv,2010,3:715-722.
• [20]Fearon WF,Shah M,Ng M,et al.Predictive value of the index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction.J Am Coll Cardiol,2008,51:560-565.
• [21]Fearon WF,Low AF,Yong AS,et al.Prognostic value of the Index of Microcirculatory Resistance measured after primary percutaneous coronary intervention.Circulation,2013,127:2436-2441.
• [22]Lim HS,Yoon MH,Tahk SJ,et al.Usefulness of the index of microcirculatory resistance for invasively assessing myocardial viability immediately after primary angioplasty for anterior myocardial infarction.Eur Heart J,2009,30:2854-2860.
• [23]Yoo SH,Yoo TK,Lim HS,et al.Index of microcirculatory resistance as predictor for microvascular functional recovery in patients with anterior myocardial infarction.J Korean Med Sci,2012,27:1044-1050.
• [24]Layland JJ,Whitbourn RJ,Burns AT,et al.The index of microvascular resistance identifies patients with periprocedural myocardial infarction in elective percutaneous coronary intervention.Heart,2012,98:1492-1497.