许田,葛震,张俊杰,叶飞,田乃亮,陈绍良

• 1:江苏南京市第一医院心内科

摘要(Abstract)：

目的本研究旨在针对左冠状动脉前降支(LAD)单支病变的不稳定型心绞痛(UA)患者,探讨定量冠状动脉造影(QCA)和血管内超声(IVUS)预测冠状动脉血流储备分数(FFR)<0.80的最佳临界值。方法连续入选169例LAD单支病变的患者,分别测定QCA、IVUS和FFR。使用受试者工作曲线(ROC)建立QCA和IVUS测定值预测FFR<0.80的价值。结果 99例患者(58.6%)FFR<0.80。最小管腔面积(MLA)和斑块负荷(PB)是预测FFR<0.80的两个独立因子。病变长度预测FFR<0.80的价值较小。MLA和PB预测总体LAD病变的FFR<0.80的临界值分别为3.03mm2和75.4%。MLA和PB对LAD近端(临界值分别为3.04 mm2和76.5%)及远端(临界值分别为2.82 mm2和80.6%)病变具有相似的诊断价值。联合MLA(2.82 mm2)和PB(80.6%)对于诊断远端LAD具有更大的意义。结论当病变局限在LAD时,MLA和PB预测FFR<0.80具有相似的诊断价值。联合MLA和PB对预测远端LAD病变的功能学意义具有更大的价值。

关键词(KeyWords)： 定量冠状动脉造影;血管内超声;血流储备分数;受试者工作特征曲线;诊断价值

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 许田,葛震,张俊杰,叶飞,田乃亮,陈绍良

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