张东凤,吕树铮,宋现涛

• 1:首都医科大学附属北京安贞医院心内科北京市心肺血管疾病研究所

摘要(Abstract)：

目的评价巨噬细胞集落刺激因子(M-CSF)、白细胞介素-10(IL-10)、白细胞介素-6(IL-6)、高敏C反应蛋白(hs-CRP)以及基质金属蛋白酶-9(MMP-9)与轻中度冠状动脉狭窄患者斑块形态学特征的相关性。方法连续纳入就诊于首都医科大学附属北京安贞医院并行冠状动脉造影证实为轻中度狭窄的患者566例,包括动脉粥样硬化269例(AS组)、稳定型心绞痛82例(SAP组)、不稳定型心绞痛193例(UAP组)和急性心肌梗死22例(AMI组)。对靶血管行定量冠状动脉造影(QCA)分析,应用绝对定量蛋白芯片法测定5种炎性因子的水平,分析炎性因子水平与冠状动脉病变形态学特征的相关性。结果 M-CSF水平与冠状动脉直径狭窄率存在正相关(r=0.115,P=0.008)。以直径狭窄率为因变量进行多元线性回归分析,发现M-CSF、吸烟、年龄与冠状动脉直径狭窄率有线性回归关系;而IL-10、IL-6、hs-CRP、MMP-9水平与病变最小管腔直径、直径狭窄率、病变长度、最小管腔面积、面积狭窄率、斑块面积均无显著相关性。结论 M-CSF与冠状动脉直径狭窄率存在正相关,而IL-10等其他因子并不适合用于判断斑块的形态学指标。

关键词(KeyWords)： 冠心病;巨噬细胞集落刺激因子;基质金属蛋白酶-9;定量冠状动脉造影

Abstract:

Keywords:

基金项目(Foundation): 北京市科委科技计划(D0906006000091)

作者(Author): 张东凤,吕树铮,宋现涛

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