朱博文,苏晓灵

• 1:青海大学研究生院
• 2:青海省人民医院心血管内科

摘要(Abstract)：

冠状动脉慢血流现象是一种无明显管腔狭窄,但出现血流缓慢的现象。近年来这种现象引起了许多学者的关注与研究,并且在研究中发现了有可能引起此病的几种致病机制。现对这几种机制及危险因素进行综述。

关键词(KeyWords)： 冠状动脉;慢血流;机制;危险因素

Abstract:

Keywords:

基金项目(Foundation): 青海省卫生健康委员会项目基金（2018-wjzd-02）;; 青海省科学技术厅应用基础研究计划项目基金（2019-ZJ-7039）

作者(Author): 朱博文,苏晓灵

参考文献(References)：

• [1]王苏，孙涛，孙俊平，等.冠状动脉慢血流现象影响因素研究.中华实用诊断与治疗杂志，2012, 26(11):1048-1050.
• [2]何永福，孙林，林志.冠状动脉慢血流现象病理生理机制及治疗进展.心血管病学进展，2018, 39(3):448-452.
• [3]邓勇，马晓峰，王红，等.世居高原地区藏族、汉族冠状动脉慢血流现象患者凝血功能指标、红细胞相关指标及胆红素差异的病例对照研究.实用心脑肺血管病杂志，2020, 28(3):51-55.
• [4] Zhu YT, Zhu LP, Wang ZY, et al. Plasma choline as a diagnostic biomarker in slow coronary flow. Cardiol Res Pract, 2020, 2020:7361434.
• [5] Wang Z, Klipfell E, Bennett BJ, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature,2011, 472(7341):57-63.
• [6] Bhat OM, Kumar PU, Giridharan NV, et al. Interleukin-18-induced atherosclerosis involves CD36 and NF-κB crosstalk in Apo E-/-mice. J Cardiol, 2015, 66(1):28-35.
• [7] Sivalingam Z, Larsen SB, Grove EL, et al. Neutrophil gelatinaseassociated lipocalin as a risk marker in cardiovascular disease. Clin Chem Lab Med, 2017, 56(1):5-18.
• [8] Tuttolomondo A, Di Raimondo D, Pecoraro R, et al. Atherosclerosis as an inflammatory disease. Curr Pharm Des, 2012, 18(28):4266-4288.
• [9]李建军.冠状动脉慢血流综合征与炎症的关系.中国动脉硬化杂志，2009, 17(1):1-3.
• [10]赵子威，杨杰，刘妍，等.冠状动脉慢血流的相关危险因素分析.中国医药，2020, 15(7):1004-1007.
• [11] Yesin M，?a?da?M, Karaba?Y, et al. Assessment of the relationship between C-reactive protein-to-albumin ratio and slow coronary flow in patients with stable angina pectoris. Coron Artery Dis, 2019, 30(7):505-510.
• [12]陈柏荣，危小良，彭湖，等.髓过氧化物酶与冠状动脉慢血流的相关性.中国动脉硬化杂志，2015, 23(2):185-187.
• [13] Yayla?，Akbo?a MK, Gayretli-Yayla K, et al. A novel marker of inflammation in patients with slow coronary flow:lymphocyte-tomonocyte ratio. Biomark Med, 2016, 10(5):485-493.
• [14] Turhan H, Saydam GS, Erbay AR, et al. Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow. Int J Cardiol, 2006,108(2):224-230.
• [15] Kundi H, Gok M, Cetin M, et al. Association of thiol disulfide homeostasis with slow coronary f low. Scand Cardiovasc J,2016, 50(4):213-217.
• [16] Wang T, Dong AH, Cao HY. Serum salusin-βlevels are correlated with slow coronary flow. Genet Test Mol Biomarkers,2016, 20(7):393-397.
• [17] Koya T, Miyazaki T, Watanabe T, et al. Salusin-βaccelerates inflammatory responses in vascular endothelial cells via NF-κB signaling in LDL receptor-deficient mice in vivo and HUVECs in vitro. Am J Physiol Heart Circ Physiol, 2012, 303(1):H96-H105.
• [18] Cakmak HA, Aslan S, Gul M, et al. Assessment of the relationship between a narrow fragmented QRS complex and coronary slow flow.Cardiol J, 2015, 22(4):428-436.
• [19] Liu J, Ren YG, Zhang LH, et al. Serum salusin-βlevels are associated with the presence and severity of coronary artery disease. J Investig Med, 2015, 63(4):632-635.
• [20] Tanriverdi H, Evrengul H, Kuru O, et al. Cigarette smoking induced oxidative stress may impair endothelial f unction and coronary blood f low in angiographically normal coronary arteries. Cir J, 2006, 70(5):593-599.
• [21]慢性间歇低氧（CIH）的危害及其发生机制专题论坛.中华医学杂志，2011,91(24):1717.
• [22]康晶.慢性间歇低氧与慢性持续低氧对血管内皮功能及心肌收缩功能影响的比较.武汉：武汉大学，2018.
• [23]李晓倩，周宸，胡月红，等.藏族与汉族肺栓塞患者的危险因素及预后比较.中华医学杂志，2018, 98(40):3249-3252.
• [24]吴焱贤，钟建开，陈玉映，等.急诊介入慢血流的发生及预后与同型半胱氨酸水平的相关性.南方医科大学学报，2013, 33(3):416-419.
• [25] Yucel H, Ozaydin M, Dogan A, et al. Plasma concentrations of asymmetric dimethylarginine, nitric oxide and homocysteine in patients with slow coronary flow. Scand J Clin Lab Invest,2012, 72(6):495-500.
• [26] Celotto AC, Fukada SY, Laurindo FR, et al. Chronic hyperhomocysteinemia impairs vascular function in ovariectomized rat carotid arteries. Amino Acids,2010, 38(5):1515-1522.
• [27] Li N, Tian L, Ren J, et al. Evaluation of homocysteine in the diagnosis and prognosis of coronary slow flow syndrome. Biomark Med, 2019, 13(17):1439-1446.
• [28]王永，杨慧敏，陈燕，等.冠状动脉慢血流现象临床因素分析与内皮功能评价.中国介入心脏病学杂志，2018,26(9):517-522.
• [29]剡冬冬，彭瑜，赵晶，等.冠状动脉慢血流现象临床危险因素及形态学研究.中国介入心脏病学杂志，2021,29(1):29-34.