王芳,陶凌,张剑桥,高超,刘建正,杨旺伟,牟方俊,张亮,王欢,张亚敏,郭春棉,杨华,贺媛

• 1:中国人民解放军空军军医大学第一附属医院心血管内科
• 2:中国人民解放军空军军医大学基础医学院学员四大队

摘要(Abstract)：

目的 通过冠状动脉造影微循环阻力指数（caIMR）评估急性ST段抬高型心肌梗死（STEMI）患者经皮冠状动脉介入治疗（PCI）术后即刻与随访6个月时冠状动脉微循环功能的变化，进而预测患者术后1年心脏功能的变化。方法 纳入TARGET STEMI OCT China研究中符合caIMR测量的患者30例，测量直接PCI术后即刻（caIMR_0）及随访6个月（caIMR_6）冠状动脉造影的caIMR值，通过线性回归方法分析冠状动脉微循环功能的变化对STEMI患者1年心脏功能的影响。结果 30例患者caIMR_0(41.70±12.22)U,caIMR_6(28.74±10.05)U。caIMR_6与caIMR_0的差值△caIMR（–12.96±13.08)U。线性回归分析发现，△caIMR与术后1年的左心室射血分数（LVEF）呈负相关（P=0.023,r=–0.414），△caIMR对患者长期预后具有一定的预测价值。协方差分析发现，靶病变血管为左前降支（β=10.18,P=0.016）及新生内膜厚度（β=0.11,P=0.039）与caIMR_6成正相关。结论 STEMI患者△caIMR对术后1年的LVEF具有预测价值，二者成负相关。△caIMR越小时，术后1年的LVEF恢复越好。

关键词(KeyWords)： ST段抬高型心肌梗死;冠状动脉造影微循环阻力指数;冠状动脉微循环功能;心脏功能

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金青年项目（82100362）;; 中国人民解放军空军军医大学第一附属医院2018年度学科助推计划（XJZT18MJ40）

作者(Author): 王芳,陶凌,张剑桥,高超,刘建正,杨旺伟,牟方俊,张亮,王欢,张亚敏,郭春棉,杨华,贺媛

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