青年人血清尿酸水平与冠心病的相关性研究Relationship of serum uric acid level to risk of coronary heart disease in young adults less than 45 years old in age
梁金峰,李伟山,李建平
摘要(Abstract)：
目的探讨青年人血清尿酸水平与冠心病的关系。方法2005年1月至2008年4月在北京大学第一医院接受冠状动脉造影检查的年龄≤45岁的住院患者共156例。按照造影结果,分为冠心病组(96例)和对照组(60例)。冠心病组又分为单支病变亚组(55例)、双支病变亚组(21例)和三支病变亚组(20例)。分析血清尿酸水平与冠心病及冠状动脉病变严重程度的关系。结果冠心病组血清尿酸水平显著高于对照组(347.3±77.8 mmol/L比306.1±76.6 mmol/L,P<0.01),并且随着冠状动脉受累支数的增多,血清尿酸水平逐渐增高(单支病变亚组322.8±74.6 mmol/L,双支病变亚组373.8±59.3 mmol/L,三支病变亚组383.6±82.1 mmol/L,P<0.01)。经Cumulative Logit模型分析,在调整了其他危险因素后,血清尿酸水平仍与冠状动脉病变支数独立相关(OR=1.008,95%CI:1.003~1.013,P<0.01)。结论在本组青年人群中,血清尿酸水平升高与冠心病及冠心病的严重程度具有显著相关性,而且在青年人群中,血清尿酸水平升高是冠心病发病的独立危险因素。
关键词(KeyWords)： 青少年;冠状动脉疾病;尿酸
基金项目(Foundation):
作者(Author): 梁金峰,李伟山,李建平
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