血栓负荷重对老年急性心肌梗死患者急诊介入治疗预后的影响Effects of high-burden thrombus on prognosis of emergency percutaneous coronary intervention in elderly patients with acute myocardial infarction
李东宝,华琦,刘志,王珊,金尉英
摘要(Abstract):
目的探讨血栓负荷重对老年ST段抬高急性心肌梗死患者急诊经皮冠状动脉介入治疗(PCI)预后的影响。方法73例老年ST段抬高急性心肌梗死患者在发病12h内行急诊PCI。根据冠状动脉造影后血栓负荷状态分为血栓负荷重组(n=26)和血栓负荷轻组(n=47),同时监测PCI后血流、肌酸激酶MB型同工酶(CK-MB)峰值、住院期间的射血分数(EF)和病死率。结果梗死相关血管内血栓负荷过重的发生率为35.6%,多见于右冠状动脉内。血栓负荷重组患者行PCI后TIMI3级血流的发生率明显低于血栓负荷轻组;血栓负荷重组的CK-MB峰值和近期死亡率明显高于血栓负荷轻组。结论血栓负荷过重是老年急性心肌梗死患者急诊PCI预后的危险因素。
关键词(KeyWords): 心肌梗死;老年人;预后;血栓负荷
基金项目(Foundation):
作者(Author): 李东宝,华琦,刘志,王珊,金尉英
参考文献(References):
- [1]Muller DWM,Topol EJ.Selection of patients with acute myocardial infarction for thrombolytic therapy.Ann Intern Med,1990,113:949-960.
- [2]Gillum RF.Trends in acute myocardial infarction and coronary heart disease death in the United States.J AmColl Cardiol,1993,23:1273-1277.
- [3]Ito H.No-reflow phenomenon and prognosis in patients with a-cute myocardial infarction.Nat Clin Pract Cardiovasc Med,2006,9:499-506.
- [4]Reffelmann T,Kloner RA.The no-reflow phenomenon:a basic mechanism of myocardial ischemia and reperfusion.Basic Res Cardiol,2006,101:359-372.
- [5]Burzotta F,Trani C,Romagnoli E,et al.A pilot study with a new rapid exchange thrombus aspirating device in patients with thrombus containing lesion:the Diver C.E study.Catheter Card-iovsc Interv,2006,67:887-893.
- [6]Zijlstra F,deBoer MJ,Beukema WP,et al.Mortality reinfarction left ventricular ejection fraction and costs following reperfusion therapies for acute myocardial infarction.Eur Heart J,1996,17:382-387.
- [7]Laster SB,Rutherford BD,GriorgiLV,et al.Results of direct per-cutaneous transluminal coronary angioplasty in octogenarians.Am J Cardiol,1996,77:10-13.
- [8]Chen Fang,Jia Sanging,Hudayi,et al.Direct percutaneous trans-luminal coronary angioplasty experience in acute myocardial in-farction.Chin J Cardiol,1999,27:87-89.
- [9]Rezkalla SH,Klooner RA.No2reflow phnomenon.Circulation,2002,105:656-662.
- [10]Singh M,Ting HH,Araujo NA,et al.Influence of thrombus on the outcome of coronary interventions in the currentera.J Am Coll Cardiol,2000,35:90A
- [11]Cafri C,Svirsky R,Gilutz H,et al.Better procedural results in coronary thrombosis are obtained with delayed percuaneous coro-nary intervention.J Am Coll Cardiol,2001,37:34A
- [12]Giri S,Kieman JF,Hist JA,et al.Intracoronary thrombus is a marker for adverse angiographic and clinical outcomes in patients undergoing primary angioplasty.Circulation,1998,98:17.
- [13]Sianos G,Papafklis MI,Daemen J,et al.Angiographic stent thrombosis after routine use of drug-eluting stents in ST-segment elevation myocardial infarction:the importance of thrombus bur-den.J Am Coll Cardiol,2007,50:573-583.
- [14]张大鹏,王乐丰,杨新春,等.急性ST段抬高心肌梗死急诊介入治疗后心肌组织水平再灌注不良的靶病变冠状动脉造影特征.中华心血管病杂志,2008,36:291-296.
- [15]Sakuma T,Leong PH,Fisher NG,et al.Further insights into the no reflow phenomenon after primary angioplasty in acute myocar-dial infarction:the role of microthromboembeli.J Am Soc Echo-cardiogr,2003,16:15-21.
- [16]Yip HK,Chen MC,Chang HW,et al.Angiographic morphologic feature of infarct related arteries and timely reperfusion in acute myocardial infarction:predictors of slow flow and no reflow phe-nomenon.Chest,2002,122:1322-1332.
- [17]董振宇,周旭晨,张国春,等.急性心肌梗死相关右冠状动脉血栓负荷的影响因素分析.中国心血管病研究,2007,5:682-684.