人趋化素样因子1促使大鼠心肌梗死后心肌细胞增殖Human chemokine-like factor 1 can improve the poliferation of cardiomyocytes after acute myocardial infarction in rats
刘倩竹,洪涛,杨波,冯雪茹,龚艳君,卜定方,薛林,赵春玉,霍勇
摘要(Abstract)：
目的初步研究人趋化素样因子(CKLF)1改善大鼠急性心肌梗死后心功能的机制。方法选取18只雄性SD大鼠,随机分为三组,每组6只,分别肌肉电转CKLF1质粒、空质粒及盐水。电转后第6天构建大鼠急性心肌梗死模型。电转后第27天处死大鼠,行BrdU/α-actin、Ki67/α-actin免疫组化染色。结果CKLF1组梗死周边区BrdU阳性细胞明显多于盐水组及空质粒组(33.11±2.10个/高倍视野比14.16±1.63个/高倍视野、18.46±2.77个/高倍视野,P<0.05);CKLF1组梗死周边区Ki67阳性细胞明显多于盐水组及空质粒组(35.20±8.06个/高倍视野比15.96±3.58个/高倍视野、17.52±2.66个/高倍视野,P<0.05)。盐水组与空质粒组相比,各指标差异无统计学意义。结论CKLF1可以促进心肌梗死后大鼠心肌细胞增殖。
关键词(KeyWords)： 心肌梗死;趋化因子类;细胞增殖
基金项目(Foundation): 国家自然科学基金(30470694)资助
作者(Author): 刘倩竹,洪涛,杨波,冯雪茹,龚艳君,卜定方,薛林,赵春玉,霍勇
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