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<正> The safe and efficacy of diltiazem in ventricular rate control of atrialfibrillation are the major concern to most clinicians in patients with heartfailure.We tested the performance of acute application of diltiazem inpatients with heart failure and atrial fibrillation or flutter.A total of 280patients were grouped according to the New York heart failureclassification,with class IV in 48 patients.All the patients receiveddiltiazem 10-20mg intravenous injection and/or 10mg/h intravenousinfusion during arrhythmia.After the drag injection or infusion,theventricular rate decreased from 142.09±17.61 to 100.24±17.74 beatper minute(P<0.0001),the systolic blood pressure dropped from135.44+28.14 to 123.52±19.18 mmHg(P<0.001),the diastolic bloodpressure dropped from 84.52±16.04 to 77.26±12.02mmHg(P<0.01).Despite the decrease in blood pressure,no deteriorate symptom wasnoted in all the groups of patients.Our results suggest that the diltiazemis a safe and effective drug to control the ventricular rate during atrialfibrillation or flutter associated with heart failure.

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