~(99)Tc~m-MIBI门控心肌灌注显像评价尼可地尔对冠状动脉慢血流的疗效Effect of nicorandil on coronary slow flow evaluated by 99Tcm-MIBI gated myocardial perfusion imaging
王涛,张慧平,李远,肖文良,姜志安,殷洪山
摘要(Abstract)：
目的采用99Tcm-MIBI门控心肌灌注显像(GMPI)技术观察尼可地尔对冠状动脉慢血流(CSF)的临床疗效。方法选取经冠状动脉造影诊断为CSF的患者83例,按照随机抽签分为对照组42例和尼可地尔组41例。对照组给予常规抗心绞痛药物治疗,尼可地尔组在对照组用药基础上加服尼可地尔。于治疗前和治疗后6个月分别行GMPI检查以评估心肌受损的程度。结果用药6个月后,尼可地尔显著改善患者心肌缺血总评分和平均缺血心肌节段数(P=0.001,P=0.000)。但治疗前后,两组患者左心室射血分数(LVEF)、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)比较,差异均无统计学意义(P>0.05)。结论尼可地尔能进一步改善CSF患者的心肌灌注。
关键词(KeyWords)： 冠状动脉慢血流;尼可地尔;门控心肌灌注显像
基金项目(Foundation):
作者(Author): 王涛,张慧平,李远,肖文良,姜志安,殷洪山
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