常书福,朱雯晴,马剑英,李晨光,戴宇翔,陆浩,葛雷,钱菊英,葛均波

• 1:上海复旦大学附属中山医院心内科

摘要(Abstract)：

目的观察因血栓高负荷未能行初次经皮冠状动脉介入治疗(PCI)的急性ST段抬高心肌梗死患者围术期抗栓治疗对择期PCI的影响。方法回顾性分析8例急性ST段抬高心肌梗死患者初次行冠状动脉造影术,因靶血管血栓高负荷不能行支架置入术。分析所有患者围术期抗栓治疗方案、术中处理方案及随访情况。结果所有8例患者均为男性,平均年龄(51.25±10.81)岁。吸烟史是最常见的危险因素。右冠状动脉大量血栓堵塞导致急性下壁心肌梗死最多见。3例患者未行PCI,1例仅行单纯血栓抽吸,4例患者行血栓抽吸及球囊扩张术。7例患者术中、术后均给予替罗非班治疗;术后6例患者给予低分子肝素抗凝;7例患者常规双联抗血小板治疗(阿司匹林100 mg、每日1次+氯吡格雷75 mg、每日1次或替格瑞洛90 mg、每日1次),1例患者阿司匹林剂量增加至200 mg,氯吡格雷增加至每日2次。平均(29.00±23.25)d后复查冠状动脉造影,2例患者因仍存在血栓高负荷,未尝试行PCI;1例患者因血管扭曲,球囊不能送至闭塞病变处,未能成功置入支架;2例患者因血栓负荷过重,球囊扩张后,未行支架置入术;3例患者成功行支架置入术。结论急性ST段抬高心肌梗死患者因靶血管血栓高负荷初次开通血管失败,常规抗栓治疗方案对血栓高负荷的清除作用有限,血栓完全机化、择期PCI的时机尚不清楚,仍需进一步研究探讨。

关键词(KeyWords)： 急性ST段抬高心肌梗死;血栓负荷;经皮冠状动脉介入治疗;抗栓治疗

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 常书福,朱雯晴,马剑英,李晨光,戴宇翔,陆浩,葛雷,钱菊英,葛均波

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