常晶,刘宇,吕亚奇,胡小兰,张丽,彭晓霞,张麟

• 1:首都医科大学附属北京朝阳医院综合科
• 2:首都医科大学附属北京朝阳医院心脏中心
• 3:首都医科大学公共卫生学院

摘要(Abstract)：

目的评价缺血后适应治疗急性ST段抬高心肌梗死患者减少心肌梗死面积及对主要不良心血管事件的疗效,探讨其适宜的人群及方案。方法检索Cochrane、PubMed、EMBASE、万方数据库、中国期刊全文数据库和中国生物医学文献数据库,根据纳入和排除标准筛选文献并评价、提取数据,应用RevMan 5.2和STATA 12软件分别进行Meta分析与Meta回归分析。结果共纳入临床研究24项(2222例)。发现缺血后适应能显著减少心肌梗死而积[SMD-0.35,95%CI-0.72~0.07,P<0.00001,I~2=85%,n=890]。Meta回归分析发现缺血后适应对年轻患者更能减少心肌梗死面积;操作方案60 s/60 s×4优于其他方案;在主要不良心血管事件方面差异无统计学意义(RR合并0.92,95%CI0.67~1.25,P=0.58,n=1449)。结论缺血后适应显著减少心肌梗死面积,对年轻患者更有益,且60 s/60 s×4方案效果更好,但在主要不良心血管事件方面无显著益处。

关键词(KeyWords)： 缺血后适应;心肌梗死;经皮冠状动脉介入治疗;治疗效果

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 常晶,刘宇,吕亚奇,胡小兰,张丽,彭晓霞,张麟

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