张瑞涛,田振宇,周继升,郭丽君,徐昕晔

• 1:北京大学第三医院心内科血管医学研究所血管稳态与重构全国重点实验室国家卫生健康委心血管分子生物学与调节肽重点实验室心血管受体研究北京市重点实验室

摘要(Abstract)：

目的 以血流储备分数（FFR）为金标准，比较定量血流分数（QFR）与静息全周期比值（RFR）评估冠状动脉临界病变的准确性及临床应用价值。方法 回顾性纳入2020年9月至2022年1月，在北京大学第三医院因冠状动脉性心脏病行冠状动脉造影并同时接受FFR和RFR检测的142例患者142支血管病变，分析RFR、QFR与FFR的线性相关性和诊断一致率，并进行受试者工作特征（ROC）曲线分析。根据性别及靶血管进行亚组分析。结果 142例患者年龄66(58,71)岁，87例（61.3%）为男性，110支（77.5%）靶病变位于左前降支，RFR与FFR相关性r=0.814(95%CI 0.748～0.864,P<0.0001)、QFR与FFR相关性r=0.617(95%CI0.503～0.709,P<0.0001)，均存在显著线性相关关系。RFR对应FFR≤0.80的AUC0.786(95%CI0.715～0.857)，而QFR对应FFR≤0.80的AUC 0.707(95%CI0.633～0.782)，两者之间的AUC差异无统计学意义（P=0.056）。在不同性别及靶病变的亚组分析中，RFR和QFR的AUC差异均无统计学意义（均P>0.05）。结论 RFR、QFR与FFR有较高的一致性，二者与FFR诊断一致率较高，性别和靶病变对二者诊断准确性影响较小。

关键词(KeyWords)： 静息全周期比值;血流储备分数;定量血流分数

Abstract:

Keywords:

基金项目(Foundation): 北京大学第三医院创新转化基金项目（BYSYZHKC 2022106）

作者(Author): 张瑞涛,田振宇,周继升,郭丽君,徐昕晔

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