韩春雨,木胡牙提,张雷,杨玉春,哈斯达尔,刘志强

• 1:新疆医科大学第一附属医院综合心脏内科

摘要(Abstract)：

目的探讨急性冠状动脉综合征(ACS)患者中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)与冠状动脉狭窄程度及院内主要不良心血管事件(MACE)发生的关系。方法收集2018年4月至2020年4月于新疆医科大学第一附属医院初次行冠状动脉造影ACS患者(426例)的临床基本资料、实验室参数,根据住院MACE情况,将纳入的患者分为MACE组(104例)和无MACE组(322例)。根据Gensini评分的三分位数,将患者分为三组:低Gensini组(≤34分,143例),中Gensini组(34～58分,142例),高Gensini组(>58分,141例),使用t检验、方差分析、卡方检验、非参数Mann-Whitney U检验、Kruskal-Wallish H检验、logistic回归分析和受试者工作特性曲线等统计方法对数据进行分析。结果 MACE组NLR[4.48(2.42,7.47)比2.82(1.79,4.70),P<0.001]和PLR[133.21(92.88,190.25)比101.03(75.33,134.01),P<0.001]显著高于无MACE组,差异有统计学意义。在基于Gensini评分分组的三组中,低Gensini组、中Gensini组、高Gensini组NLR[3.59(1.56,3.58)比3.47(1.94,5.73)比3.71(2.13,6.21),P<0.001]、PLR[93.98(66.03,127.94)比110.90(88.26,140.79)比120.37(84.58,174.54),P<0.001]比较,差异均有统计学意义。logistic回归分析显示,NLR(OR 1.189,95%CI 1.003～1.409,P=0.046;OR 1.102,95%CI 1.005～1.208,P=0.039)、PLR(OR 1.008,95%CI 1.002～1.014,P=0.021;OR 1.004,95%CI 1.002～1.009,P=0.042)是院内MACE和高Gensini评分的独立危险因素。NLR预测院内MACE发生的截断值为4.516,敏感度为50.00%,特异度为74.53%,曲线下面积(AUC)为0.633(95%CI 0.585～0.679,P<0.001);PLR预测院内MACE发生的截断值为153.103,敏感度为45.19%,特异度为84.78%,AUC为0.666(95%CI 0.619～0.711,P<0.001)。NLR预测高Gensini评分(>58分)的截断值为3.802,敏感度为49.62%,特异度为66.44%(AUC=0.600,95%CI0.552～0.647,P<0.001);PLR预测高Gensini评分的截断值为153.543,敏感度为37.40%,特异度为84.75%(AUC=0.616,95%CI 0.567～0.662,P<0.001)。结论 NLR、PLR作为一种新的炎症标志物,与ACS患者院内MACE的发生和冠状动脉狭窄的严重程度有显著的独立相关性。NLR、PLR作为一种容易获得且价格便宜的炎症指标,可作为有效的炎症标志物广泛应用于鉴别高危患者,从而有助于指导个体化治疗以改善ACS预后。

关键词(KeyWords)： 急性冠状动脉综合征;中性粒细胞/淋巴细胞比值;血小板/淋巴细胞比值;主要不良心血管事件;Gensini评分

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金（81760062）

作者(Author): 韩春雨,木胡牙提,张雷,杨玉春,哈斯达尔,刘志强

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