摘要(Abstract)：

<正> Calcitonin gene-related peptide(CGRP)has the effect of antiarrhyth-mic,expectally to ischemtc arrhythmia.But up to now,it's electro-physiological mechanism is not known very clearly.In this study,theaction potential and resting membrane potential(RP)in rabbit my-ocardial were recorded with standard glass microelectrodes tech-nique,the electrophysiotogical effects of CGRP on normal and simu-lated ischemtc condition were observed.The results showed that:(1)In normal condition,after afflication of CGRP(the concentration ofCGRP was 1×10~(-8)M,CGRP was purchased from sigma chemicalCo),RP and action potential amplltude(APA)increased significantly(P<0.01),the action potential duration(APD_(30),APD_(50))were notchanged obviously,but the APD_(90)was shorted obviously(P<0.05).(2)In simulated ischemic condition,CGRP had the same effects onRP and APA as normal condition.It prolonged the APD_(30)and APD_(50)obviously(P<0.05)and shorted the APD_(90)signficantly.This indicat-ed that CGRP could reverse the abnormal changes caused by ischemi-a.These results demonstrated that CGRP had stabilizing and protec-tive effects on ischemical myocardial.

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