梅卫义,杜志民,胡承恒,伍贵富,李怡,罗初凡,陈国伟

• 1:中山大学附属第一医院心内科

摘要(Abstract)：

目的探讨急性冠状动脉综合征(ACS)患者循环妊娠相关血浆蛋白A(PAPP-A)水平与冠状动脉介入治疗(PCI)术前和术后心肌灌注的关系。方法高危非ST段抬高ACS患者44例,PCI术前分别检测其血PAPP-A、心肌钙蛋白T(cTnT)和肱动脉血流介导的血管舒张反应(FMD),并分析它们与PCI术前和术后罪犯血管供血区域的TIMI心肌灌注分级(TMPG)的关系。结果术前TMPG0～1级患者20例,其PAPP-A水平高于TMPG2～3级患者(30.41±21.33mIu/L比23.55±18.61mIu/L,P=0.036),而FMD低于TMPG2～3级患者(2.95%±1.71%比3.54%±1.58%,P=0.027);术后TMPG0～1级患者12例,其PAPP-A水平高于TMPG2～3级患者(35.64±20.58mIu/L比21.87±19.30mIu/L,P=0.009),FMD低于后者(2.26%±1.83%比3.95%±1.43%,P=0.018)。结论高危非ST段抬高ACS患者的心肌组织灌注与PAPP-A水平和FMD有一定关系,这可能是PAPP-A影响ACS患者预后的机制之一。

关键词(KeyWords)： 冠状动脉疾病;妊娠相关血浆蛋白A;心肌再灌注

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 梅卫义,杜志民,胡承恒,伍贵富,李怡,罗初凡,陈国伟

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