左旋精氨酸防治血管内皮损伤后再狭窄的实验研究The experimental study of L-arginine preventing restenosis after arterial endothelial injury
陈洪江,朱国英
摘要(Abstract)：
本研究利用3H－TdR参入试验和计算机图像分析方法观察了内皮源性舒张因子的前体左旋精氨酸对内皮损伤的大鼠胸主动脉内膜增生的影响，为其作为临床防治再狭窄的可行性提供实验依据。结果发现大鼠胸主动脉内皮损伤后，内膜增生明显，3H－TdR参入量显著上升，而左旋精氨酸可使血管新生内膜增生程度明显减轻，3H－TdR参入量显著下降。表明左旋精氨酸对动脉内皮损伤后的内膜增生有明显抑制作用，提示其在临床再狭窄的防治上可能将有良好的应用前景。
关键词(KeyWords)： 左旋精氨酸;内皮损伤;内膜增生
基金项目(Foundation):
作者(Author): 陈洪江,朱国英
参考文献(References)：
- 1陈洪江,朱国英.内皮损伤后的大鼠胸主动脉血管反应性的动态观察.中国介入心脏病学杂志,1995,3:122-124.
- 2 Mcmurry HF,Parrt DP,Dowyer DE. Standardsed methodof culturing aortlc expfants,suitable for tile study of factorsaffecting the phenotypeic modulation,migration andproliferation of aortlc smooth muscle cell Atherosclerosls,1991,86:227
- 3 Ignsrro LJ. Endothelium-derived nitric oxide:actions andproperties FASEB J,1989.3:3136.
- 4 Nakike T,Makayama M,Kato R. Inhibition by nitric oxideand nitric oxide-producing vasodilators of DNA syntnesis invascular smooth muscle cells. Eur J Pharmacol,1990,189:347-353.
- 5Yu SM,Gung LM,Lin CC.cGMP-elevating agentsSuppress proliferation of vascular smooth muscle cells:by i-nhibiting the activation of epidermal growth factor signalingpathway.Circulation,1997,95:1267-1277.
- 6Didati JG,Hussain N,Ba kaki N,etal.Antiplatelet effectsof endothetium-derived relaxing factor in the coronary andperipherial circulation.J Am Coil Cardiol,1993,21:261A.
- 7Rudoph W,urschinger J. Clinical comparison of nitrpatesand sydonimine.Eur Heart J,1991,12:33-41.