罗格列酮对大鼠颈动脉球囊损伤后新生内膜及炎症因子的影响The effects of rosiglitazone on neointima and inflammatory factors after carotid artery balloon injury of rats
布伦,贾国良,张薇,韩淑芳,王海昌
摘要(Abstract)：
目的观察罗格列酮对大鼠颈动脉损伤后新生内膜及炎症因子的影响。方法将SD大鼠随机分为3组(即对照组、手术组、治疗组)。手术组及治疗组均用球囊导管扩张法损伤左侧颈总动脉,治疗组给予罗格列酮灌胃治疗。术后4h,1d和7d,用放免法检测大鼠血浆中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平。2周后取损伤血管行苏木精-伊红染色、免疫组化染色及光镜观察,计算内膜面积(NIA)、内弹力板围绕面积(IELA)、管腔狭窄指数(SI)及核转录因子-κB(NF-κB)蛋白表达的光密度值。结果罗格列酮能抑制损伤动脉新生内膜的形成,抑制NF-κB的蛋白表达,降低血浆中TNF-α和IL-6水平。结论罗格列酮可以通过抑制损伤血管的炎症反应,减轻损伤血管的再狭窄。
关键词(KeyWords)： 罗格列酮;颈动脉损伤;大鼠;血管内膜;炎症趋化因子类
基金项目(Foundation):
作者(Author): 布伦,贾国良,张薇,韩淑芳,王海昌
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