猪冠状动脉介入损伤后血管壁平滑肌细胞增生与血浆组织因子水平的关系Relationship between smooth muscle cell hyperplasia and plasma tissue factor after percutaneous coronary intervention in porcine model
李少君,李宁,李志韬,张士德,田野
摘要(Abstract)：
目的探讨猪冠状动脉介入损伤后损伤局部血管壁平滑肌细胞增生程度与血浆组织因子水平的关系。方法制作猪冠状动脉介入损伤模型,测量介入手术前后血浆组织因子浓度以及损伤局部血管壁平滑肌细胞迁移、增生情况,探讨二者之间的联系。结果30例血管标本均存在不同程度的平滑肌细胞增生,其中60%的标本达到再狭窄标准。再狭窄组术后血浆组织因子水平显著高于非再狭窄组(术后30 min 688.36±91.57 ng/L比514.87±68.73 ng/L,术后24 h 706.09±89.59ng/L比539.22±70.51 ng/L,P均<0.05);血管损伤后血管段新生内膜面积与术后各时点外周血组织因子浓度正相关(r30min=0.834,r24h=0.810,P均<0.05)。结论冠状动脉介入术后血浆组织因子水平显著升高,并且其升高程度与介入局部平滑肌细胞增生程度正相关,可能作为预测介入术后再狭窄的一项检测指标。
关键词(KeyWords)： 血管成形术,经腔,经皮冠状动脉;再狭窄;平滑肌细胞;组织因子
基金项目(Foundation):
作者(Author): 李少君,李宁,李志韬,张士德,田野
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