张明,于乐

• 1:辽宁省金秋医院 省老年病研究院 老年心脏病介入中心 心血管病急诊中心
• 2:辽宁中医药大学附属医院心内科

摘要(Abstract)：

目的对国人急性冠状动脉综合征(ACS)患者给予阿托伐他汀80 mg/次、每日一次,强化降脂治疗,评价该治疗方案对ACS患者经皮冠状动脉介入治疗(PCI)后短期强化降脂疗效及安全性。方法选取2002年8月至2014年3月辽宁省人民医院、辽宁中医药大学附属医院及辽宁省金秋医院心内科收治的ACS患者1746例,住院期间全部给予阿托伐他汀80 mg/次、每日一次,出院后坚持继续服用1~3个月,根据出院后坚持服用该剂量的时间分为三组,4周≤服用该剂量时间<8周的患者886例(A组),8周≤服用该剂量时间<12周的患者562例(B组),服用该剂量时间≥12周的患者298例(C组)。各组分别在出院后第4、8、12周,抽外周静脉血检测血脂、肝肾功能、肌酸激酶(CK)。结果血脂达标率:A组85.0%,B组86.1%,C组94.0%,总体达标率86.9%。谷丙转氨酶/天冬氨酸转氨酶(ALT/AST)>正常上限2倍者:A组1.6%,B组1.8%,C组1.0%。关节及肌肉症状:A组6.3%,B组1.4%,C组2.7%。CK轻度升高(2倍

关键词(KeyWords)： 急性冠状动脉综合征;强化他汀治疗;安全性

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 张明,于乐

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