Ca2+预处理和缺血预处理对大鼠心脏Ca2+反常损伤的影响The effect of Ca2+ preconditioning and ischemic preconditioning on Ca2+ paradox injury in rat Heart
张振刚,张钧华,汪丽惠,张敏,伍贻经
摘要(Abstract):
给离体大鼠心脏进行5次1分钟无Ca~(2+)继5分钟复Ca~(2-)灌流预处理后,可使随后Ca~(2-)反常损伤明显减轻,表现为心肌细胞蛋白质丢失量减少,冠状动脉痉挛减轻.本研究进一步应用2次10分钟缺血,继10分钟再灌注进行缺血预处理,结果显示这一方案未能减轻Ca~(2+)反常所致心肌损伤.如在Ca~(2-)预处理过程中给予腺苷A_1受体阻滞剂8-SPT,可以阻断Ca~(2+)预处理的保护作用,提示腺苷A_1受体兴奋可能是这一保护机制的重要环节.
关键词(KeyWords): 预处理;Ca~(2+)反常;心肌保护
基金项目(Foundation):
作者(Author): 张振刚,张钧华,汪丽惠,张敏,伍贻经
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