何立芸,张瑞涛,张永珍,崔鸣,韩江莉,徐昕晔,汪宇鹏,米琳,牛杰,王贵松,高炜,郭丽君

• 1:北京大学第三医院心内科
• 2:国家卫生健康委员会心血管分子生物学与调节肽重点实验室
• 3:分子心血管学教育部重点实验室
• 4:心血管受体研究北京市重点实验室

摘要(Abstract)：

目的评价瞬时无波形比值(iFR)与血流储备分数(FFR)的相关性及影响诊断一致性的因素。方法回顾性收集北京大学第三医院2015年5月至2019年4月接受i FR和FFR检测的冠心病患者,探讨二者的相关性及影响其诊断一致性的因素。结果收集60例患者80支冠状动脉的109组FFR和i FR数据,FFR和i FR中位数分别为0.80(0.74,0.85)和0.90(0.87,0.94),二者呈线性相关(r=0.780,P<0.001)。iFR预测FFR≤0.80的受试者工作特征曲线下面积为0.870,最佳临界值为iFR≤0.90,诊断一致率为77.1%。iFR"灰区"为0.88～0.94,可使44.0%的功能学评价免予使用腺苷。体重指数是二者诊断不一致的独立影响因素,与iFR≤0.89且FFR≤0.80组相比,iFR>0.89且FFR≤0.80组的参考血管直径[(3.06±0.75)mm比(2.54±0.67)mm]、最小管腔直径[1.84(1.42,2.21)mm比1.35(1.17,1.52)mm]和最小管腔面积[2.65(1.58,3.83)mm2比1.42(1.08,1.83)mm2]均较大(均P<0.05)。结论 i FR与FFR具有良好的相关性,病变局部解剖特点可能对二者的诊断一致性产生一定影响。

关键词(KeyWords)： 瞬时无波形比值;血流储备分数;冠状动脉功能学评价;冠心病

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81500267);; 中国心血管健康联盟-冠脉微血管疾病创新基金(2018-CCACMVD-08);; 北京力生健康基金会领航基金(LHJJ20140210)

作者(Author): 何立芸,张瑞涛,张永珍,崔鸣,韩江莉,徐昕晔,汪宇鹏,米琳,牛杰,王贵松,高炜,郭丽君

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