刘博罕,何昆仑,朱航,王广义

• 1:中国人民解放军总医院心血管内科

摘要(Abstract)：

<正>心房颤动(atrial fibrillation,AF)作为临床上最常见的心律失常之一,其所致的血栓栓塞现象是对AF患者危害最大的并发症,尤其在大于65岁的老年人群中,有15%~20%的缺血性卒中与其相关[1]。口服抗凝药物(oral anticoagulation,OAC)是CHA2DS2-VASc积分≥1分的非瓣膜性AF患者预防缺血性卒中的经典治疗,但在某些特定人

关键词(KeyWords)： 心房颤动;左心耳封堵术

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刘博罕,何昆仑,朱航,王广义

参考文献(References)：

• [1]马长生,霍勇,方唯一.介入心脏病学.2版.北京:人民卫生出版社,2012:789-921.
• [2]Glader EL,Sj9lander M,Eriksson M,et al.Persistent use of secondary prevention drugs declines rapidly during the first 2years after stroke.Stroke,2010,41(2):397-401.
• [3]Landmesser U,Holmes Jr DR.Left atrial appendage closure:a percutaneous transcatheter approach for stroke prevention in atrial fibrillation.Eur Heart J,2012,33(6):698-704.
• [4]Dawson AG,Asopa S,Dunning J.Should patients undergoing cardiac surgery with atrial fibrillation have left atrial appendage exclusion?Interact Cardiovasc Thorac Surg,2010,10(2):306-311.
• [5]Kanderian AS,Gillinov AM,Pettersson GB,et al.Success of surgical left atrial appendage closure:assessment by transesophageal echocardiography.J Am Coll Cardiol,2008,52(11):924-929.
• [6]Katz ES,Tsiamtsiouris T,Applebaum RM,et al.Surgical left atrial appendage ligation is frequently incomplete:a transesophageal echocardiograhic study.J Am Coll Cardiol,2000,36(2):468-471.
• [7]Kanderian AS,Gillinov AM,Pettersson GB,et al.Success of surgical left atrial appendage closure:assessment by transesophageal echocardiography.J Am Coll Cardiol,2008,52(11):924-929.
• [8]Rodeheffer RJ,Naruse M,Atkinson JB,et al.Molecular forms of atrial natriuretic factor in normal and failing human myocardium.Circulation,1993,88(2):364-371.
• [9]Inoue S,Murakami Y,Sano K,et al.Atrium as a source of brain natriuretic polypeptide in patients with atrial fibrillation.J Card Fail,2000,6(2):92-96.
• [10]Crystal E,Lamy A,Connolly SJ,et al.Left Atrial Appendage Occlusion Study(LAAOS):a randomized clinical trial of left atrial appendage occlusion during routine coronary artery bypass graft surgery for long-term stroke prevention.Am Heart J,2003,145(1):174-178.
• [11]Blackshear JL,Johnson WD,Odell JA,et al.Thoracoscopic extracardiac obliteration of the left atrial appendage for stroke risk reduction in atrial fibrillation.J Am Coll Cardiol,2003,42(7):1249-1252.
• [12]Salzberg SP,Plass A,Emmert MY,et al.Left atrial appendage clip occlusion:early clinical results.J Thorac Cardiovasc Surg,2010,139(5):1269-1274.
• [13]Ailawadi G,Gerdisch MW,Harvey RL,et al.Exclusion of the left atrial appendage with a novel device:early results of a multicenter trial.J Thorac Cardiovasc Surg,2011,142(5):1002-1009.
• [14]Bartus K,Han FT,Bednarek J,et al.Percutaneous left atrial appendage suture ligation using the LARIAT device in patients with atrial fibrillation:initialclinical experience.J Am Coll Cardiol,2013,62(2):108-118.
• [15]Gafoor S,Franke J,Bertog S,et al.Left atrial appendage occlusion in octogenarian:short-term and 1-year follow-up.Catheter Cardiovasc Interv,2014,83(5):805-810.
• [16]Price MJ,Gibson DN,Yakubov SJ,et al.Early safety and efficacy of percutaneous left atrial appendage suture ligation:results from the U.S.trans-catheter LAA ligation consortium.J Am Coll Cardiol,2014,64(6):565-572.
• [17]Chatterjee S,Herrmann HC,Wilensky RL,et al.Safety and procedural success of left atrial appendage exclusion with the Lariat device:a systematic review of published reports and analytic review of the FDA MAUDE database.JAMA Intern Med,2015,175(7):1104-1109.
• [18]Nagaraj H,Wilber D,Lakkireddy DR.The lariat for left atrial appendage closure:rehash of known literature or a true analysis?JAMA Inter Med,2015,175(11):1867-1868.
• [19]Lakkireddy D,Afzal MR,Lee RJ,et al.Short and long-term outcomes of percutaneous left atrial appendage suture ligation:Results from a US multicenter evaluation.Heart Rhythm,2016,13(5):1030-1036.
• [20]Imazio M,Brucato A,Rovere ME,et al.Colchicine prevents early postoperative pericardial and pleural effusions.Am Heart J,2011,162(3):527-532.
• [21]Viles-Gonzalez JF,Kar S,Douglas P,et al.The clinical impact of incomplete left atrial appendage closure with the Watchman device in patients with atrial fibrillation:a PROTECT AF(percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation)substudy.J Am Coll Cardiol,2012,59(10):923-929.
• [22]Mosley WJ 2nd,Smith MR,Price MJ.Percutaneous management of late leak after lariat transcatheter ligation of the left atrial appendage in patients with atrial fibrillation at high risk for stroke.Catheter Cardiovasc Interv,2014,83(4):664-669.
• [23]Yeow WL,Matsumoto T,Kar S.Successful closure of residual leak following LARIAT procedure in a patient with high risk of stroke and hemorrhage.Catheter Cardiovasc Interv,2014,83(4):661-663.
• [24]Miller MA,Gangireddy SR,Doshi SK,et al.Multicenter study on acute and long-term safety and efficacy of percutaneous left atrial appendage closure using an epicardial suture snaring device.Heart Rhythm,2014,11(11):1853-1859.
• [25]Rasekh A,Kar S,Nagaraj H,et al.Differences in experience with a new delivery device for LAA ligation among various U.S.centers.J Am Coll Cardiol,2015,65(4):404-405.
• [26]Healey JS,Crystal E,Lamy A,et al.Left Atrial Appendage Occlusion Study(LAAOS):results of a randomized controlled pilot study of left atrial appendage occlusion during coronary bypass surgery in patients at risk for stroke.Am Heart J,2005,150(2):288-293.
• [27]Holmes DR,Reddy VY,Turi ZG,et al.Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation:a randomized noninferiority trial.Lancet,2009,374(9689):534-542.
• [28]Sievert H,Lesh MD,Trepels T,et al.Percutaneous left atrial appendage transcatheter occlusion to prevent stroke in high-risk patients with atrial fibrillation:early clinical experience.Circulation,2002,105(16):1887-1889.
• [29]Ostermayer SH,Reisman M,Kramer PH,et al.Percutaneous left atrial appendage transcatheter occlusion(PLAATO system)to prevent stroke in high-risk patients with non-rheumatic atrial fibrillation:results from the international multi-center feasibility trials.J Am Coll Cardiol,2005,46(1):9-14.
• [30]Block PC,Burstein S,Casale PN,et al.Percutaneous left atrial appendage occlusion for patients in atrial fibrillation suboptimal for warfarin therapy:5-year results of the PLAATO(Percutaneous Left Atrial Appendage Transcatheter Occlusion)Study.JACC Cardiovasc Interv,2009,2(7):594-600.
• [31]Bayard YL,Omran H,Neuzil P,et al.PLAATO(percutaneous left atrial appendage transcatheter occlusion)for prevention of cardioembolic stroke in non-anticoagulation eligible atrial fibrillation patients:results from the European PLAATO study.Euro Intervention,2010,6(2):220-226.
• [32]Shetty RK,Chandra GS,Agarwal S,et al.Percutaneous left atrial appendage closure in AF using Amplatzer Cardiac Plug:First single center experience from India.Indian Heart J,2015,67 Suppl 2:S35-S39.
• [33]Sick PB,Schuler G,Hauptmann KE,et al.Initial worldwide experience with the WATCHMAN left atrial appendage system for stroke prevention in atrial fibrillation.J Am Coll Cardiol,2007,49(13):1490-1495.
• [34]Reddy VY,Holmes D,Doshi SK,et al.Safety of percutaneous left atrial appendage closure:results from the Watchman left atrial appendage system for embolic protection in patients with AF(PROTECT AF)clinical trial and the continued access registry.Circulation,2011,123(4):417-424.
• [35]Belgaid DR,Khan Z,Zaidi M,et al.Prospective randomized evaluation of the watchman left atrial appendage closure device in patients with atrial fibrillation versus long-term warfarin therapy:The PREVAIL trial.Int J Cardiol,2016,219:177-179.
• [36]Meier B,Palacios I,Windecker S,et al.Transcatheter left atrial appendage occlusion with Amplatzer devices to obviate anticoagulation in patients with atrial fibrillation.Catheter Cardiovasc Interv,2003,60(3):417-422.
• [37]Park JW,Bethencourt A,Sievert H,et al.Left atrial appendage closure with Amplatzer cardiac plug in atrial fibrillation:initial European experience.Catheter Cardiovasc Interv,2011,77(5):700-706.
• [38]Lam YY,Yip GW,Yu CM,et al.Left atrial appendage closure with AMPLATZER cardiac plug for stroke prevention in atrial fibrillation:initial Asia-Pacific experience.Catheter Cardiovasc Interv,2012,79(5):794-800.
• [39]De Backer O,Loupis AM,Ihlemann N,et al.Percutaneous left atrial appendage closure for stroke prevention.Dan Med J,2014,61(8):A4879.