于路,傅国胜,姜文兵,秦光明,王俊宏

• 1: 浙江大学医学院邵逸夫医院心内科
• 2:浙江大学医学院邵逸夫医院心内科
• 3:浙江大学医学院邵逸夫医院心内科
• 4:浙江大学医学院附属第二医院检验科

摘要(Abstract)：

目的探讨冠心病患者分泌型磷脂酶A2(sPLA2)与冠状动脉(冠脉)病变积分(CAS)及动脉硬化指数(AI)的相关性。方法冠脉造影确诊的冠心病患者173例,非冠心病患者89例做为对照组,分别以ELISA法测定其sPLA2水平;以计算机定量分析系统(QCA)分析冠脉狭窄程度并计算CAS;根据公式AI=[总胆固醇(TC)-高密度脂蛋白胆固醇(HDL-C)]/HDL-C计算AI。结果与对照组相比,冠心病患者的sPLA2明显升高(55.18±11.75u/mL比68.15±16.70u/mL,P<0.01),且sPLA2水平与CAS和AI均呈正相关(P<0.05),与HDL-C呈负相关。结论sPLA2在冠心病患者中明显增高,且与CAS呈正相关;sPLA2还与脂蛋白胆固醇分布紊乱有关,它与AI呈正相关,与HDL-C呈负相关。

关键词(KeyWords)： 冠心病;磷脂酶A;冠状动脉疾病;动脉硬化

Abstract:

Keywords:

基金项目(Foundation): 浙江省科学技术基金(2004C33045);; 卫生部国际交流中心默沙东科研基金(419056-X10101)资助

作者(Author): 于路,傅国胜,姜文兵,秦光明,王俊宏

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