张译文,刘亚冬,王梦晓,王艺如,杨运鹏,苏运芳,支继新

• 1:哈尔滨医科大学附属第四医院心血管内科

摘要(Abstract)：

目的 旨在探讨冠状动脉临界病变患者空腹血糖（FBG）水平与冠状动脉血流储备分数（FFR）的相关性，阐明其对FFR测量的潜在影响。方法 回顾性收集2020年8月至2023年8月在哈尔滨医科大学附属第四医院接受冠状动脉造影检查并进行FFR评估的135例冠状动脉粥样硬化性心脏病患者资料，根据纳排标准筛选出冠状动脉造影显示管腔狭窄程度在50%～80%的冠状动脉单支血管临界病变患者85例，将其分为FBG≥6.1 mmol/L组（47例）和FBG<6.1 mmol/L组（38例）。对两组的基线资料、造影及功能学指标进行比较，并分析FBG与FFR的相关性。结果 与FBG<6.1 mmol/L组相比，FBG≥6.1 mmol/L组病变FFR>0.80比例更高（72.3%比23.7%,P<0.001），且FFR测量值普遍升高[0.84(0.80,0.90)比0.75(0.68,0.80),P<0.001]，差异均有统计学意义。对所有病变进行Spearman秩相关性分析，FFR>0.80与FBG≥6.1 mmol/L呈正相关（r=0.484,P<0.001）。结论 在本研究纳入的冠状动脉临界病变（狭窄50%～80%）患者中，FBG≥6.1 mmol/L与FFR>0.80存在相关性。对于FBG升高的冠状动脉临界病变患者群体，临床解读FFR结果时需谨慎考虑血糖因素的影响。

关键词(KeyWords)： 空腹血糖;血流储备分数;冠状动脉微循环

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 张译文,刘亚冬,王梦晓,王艺如,杨运鹏,苏运芳,支继新

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