罗涛,王永智,邓旭波,史成龙,史文举,浦奎

• 1:解放军第254医院心血管内科
• 2:解放军第254医院医务处

摘要(Abstract)：

目的探讨粒细胞集落刺激因子(G-CSF)对离体心肌梗死大鼠心室肌电生理特性的影响。方法结扎左冠状动脉建立心肌梗死模型,术后存活的67只Wistar大鼠被分为4组:Sham组、对照组、术后即刻给药组(E-G组)和延迟给药组(D-G组),利用离体心脏灌流吸附电极记录单相动作电位时程(MAP),记录有效不应期(ERP)、ERP和MAP90的离散度;常规电生理方法记录窦性心动周期(SCL)、最大动作电位幅度(APA)、零相上升最大速度(Vmax)、心室颤动阈值(VFT)及心室颤动时程(VFD)。结果心肌梗死后7 d,E-G组电生理参数(SCL、VFT、VFD、APA、ERP/MAP90、ERP和MAP90离散度)和D-G组电生理参数(SCL、ERP和MAP90离散度)较对照组均有明显改善(均P<0.05);心肌梗死后3个月,E-G组上述电生理参数较对照组延续改善(P<0.05),但D-G组除了部分电生理参数(SCL、APA、Vmax和MAP90离散度)较对照组改善(P<0.05)外,其他电生理参数较对照组无明显改善(P>0.05),ERP和MAP90甚至有恶化趋势。结论 G-CSF干预能够改善缺血心室肌电生理参数,即刻干预较延迟干预改善更明显,即刻干预电生理参数改善能够延续到缺血心室肌慢性恢复期,降低心肌梗死后室性心律失常发生率。

关键词(KeyWords)： 粒细胞集落刺激因子;心肌梗死;单相动作电位时程;离散度

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 罗涛,王永智,邓旭波,史成龙,史文举,浦奎

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