朱小凤,刘志忠,徐兢,陈绍良

• 1:南京医科大学附属南京第一医院心内科
• 2:南京红十字医院

摘要(Abstract)：

目的探讨小檗碱对心肌梗死后心室重构的影响。方法结扎新西兰兔左冠状动脉前降支,制作急性前壁心肌梗死模型。5d后随机分为治疗组[n=14,小檗碱8mg/(kg.d),耳缘静脉注射,连续5d]和对照组(n=14,注射等量生理盐水,连续5d)。干预后4周分别行血流动力学检查,测量体质量及左、右心室重量;通过免疫组织化学法检测基质金属蛋白酶(MMP)-2、MMP-9表达。结果治疗组与对照组比较,左心室重量/体质量(LVW/BW)[(1.55±0.12)×10-3比(1.69±0.13)×10-3,P<0.05]、左室舒张末压(LVEDP)均显著降低(4.76±3.56mmHg比8.21±5.88mmHg,P<0.05),左室内压最大上升速率(+dp/dtmax)和最大下降速率(-dp/dtmax)显著增加(1.54±0.26mmHg/ms比1.10±0.27mmHg/ms,P<0.05;1.67±0.38mmHg/ms比1.21±0.33mmHg/ms,P<0.05);同时梗死周边正常心肌组织MMP-2、MMP-9分布率显著减少(53.9%±3.1%比88.8%±4.5%,P<0.05及49.1%±3.9%比94.2%±6.2%,P<0.01)。结论小檗碱抑制心肌梗死后心室重构,推测和减少心肌组织MMP生成有关。

关键词(KeyWords)： 小檗碱;心肌梗死;心室重构;基质金属蛋白酶类

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 朱小凤,刘志忠,徐兢,陈绍良

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