韩雅君,卢微,王玲,田志强,董淑敏

• 1:内蒙古自治区医院心内科

摘要(Abstract)：

目的进一步探讨慢血流现象与内皮功能紊乱的相关性。方法112例冠状动脉造影正常患者,用TIMI帧数方法进行慢血流和正常血流分组。对慢血流和正常血流患者性别、年龄、胆固醇、高血压、糖尿病、吸烟、内皮素(ET)-1、一氧化氮(NO)、白介素(IL)-6等因素对比分析。结果慢血流组男性多于女性(30例比6例),吸烟患者多于不吸烟者(22例比14例)。慢血流组ET-1和IL-6水平高于正常血流组(分别为108.42±36.12pg/mL比84.74±39.16pg/mL和158.28±178.86pg/mL比108.07±84.43pg/mL,P均<0.05);慢血流组NO水平低于正常血流组(35.66±12.28μmol/L比42.74±17.51μmol/L,P<0.05)。结论慢血流现象与内皮功能紊乱相关。评价慢血流现象时要考虑影响血流的其他因素。

关键词(KeyWords)： 冠状血管;血流速度;内皮

Abstract:

Keywords:

基金项目(Foundation): 内蒙古自治区自然科学基金项目(200711020925)

作者(Author): 韩雅君,卢微,王玲,田志强,董淑敏

参考文献(References)：

• [1]Gibson CM,Cannon CP,Daley WL,et al.TIMI frame count:a quantilative method of assessing coronary artery flow.Circula-tion,1996,93:879-888.
• [2]Sezgin N,Baruteu I,Sozgin AT,et al.Plasma Nitric Oxide level and its role in slowcoronary flowphenomenon.Int Heart J,2005,46:373-382.
• [3]Celebi H,Catakoglu AB,Kurtoglu H,et al.The relation between coronary flow rate,plasma endothelin-1concentmtions,and clini-cal characteristics in patients with normal coronary arteries,Card-iovase Revase Med,2008,9:144-148.
• [4]Selcuk MT,Selcuk H,Temizhan A,et al.Asymmetric dimethyl-arginine plesma concentrations and L-arginine/asymmetric dime-thylarginine ratio in patients with slow coronary flow.Coron An-tery Dis,2007,18:545-551.
• [5]Stone GW,Brodie BR,Griffin JJ,et al.For the PAMI Stent Pi-lot Trial Investigators.Prospective,multicenter study of the safety and feasibility of primary stenting in acute myocardial infarction:in-hospital and30-day results of the PAMI stent pilot trial.J Am Coll Cardiol,1998,31:23-30.
• [6]Bickel C,Rupprecht HJ,Maimaitiming A,et al.The superiority of TIMI frame count in detecting coronary flowchanges after coro-nary stenting compared to TIMI flowclassification.J Invas Cardi-ol,2002,14:125-128.